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Biology Beyond Boundaries: Mitochondrial and Cell Death in Translational Research

Edited by:
Rajesh Gacche, PhD, Department of Biotechnology, Savitribai Phule Pune University, India
Raymond Birge, PhD, New Jersey Medical School, United States of America
Rana P. Singh, PhD, School of Life Sciences, Jawaharlal Nehru University, India
Dhyan Chandra, PhD, Roswell Park Comprehensive Cancer Center, United States of America

Submission Status: Closed   |   Submission Deadline: 31 December 2024

This collection is no longer accepting submissions.

Cell Communication and Signaling is calling for submissions to our Collection on Biology Beyond Boundaries: Mitochondrial and Cell Death in Translational Research. This Collection will aim to enhance our current understanding of mitochondrial biology, as well as exploit translational and therapeutic utilities.


New Content ItemThis collection supports and amplifies research related to SDG 3: Good Health and Well-being

  1. STX12 (syntaxin12 or syntaxin13), a member of the SNARE protein family, plays a crucial role in intracellular vesicle transport and membrane fusion. Our previous research demonstrated that Stx12 knockout mice exh...

    Authors: Dan-Hua Liu, Fang Li, Run-Zhou Yang, Zhuanbin Wu, Xiao-Yan Meng, Sen-Miao Li, Wen-Xiu Li, Jia-Kang Li, Dian-Dian Wang, Rui-Yu Wang, Shu-Ang Li, Pei-Pei Liu and Jian-Sheng Kang
    Citation: Cell Communication and Signaling 2025 23:174
    Content type: Research Published on:

  2. TNBC is an aggressive metastatic cancer that poses considerable treatment challenges because of its acquired drug resistance towards the existing targeted and hormonal therapies. The epigenetic modulation incl...

    Authors: Snehal Nimal, Navanath Kumbhar, Manasi S. Pote, Rahul Bankar, Mahemud Shaikh and Rajesh Gacche
    Citation: Cell Communication and Signaling 2025 23:163
    Content type: Research Published on:

  3. Mitochondria dysfunction has been closely linked to a wide spectrum of human cancers, whereas the molecular basis has yet to be fully understood. SLC25A35 belongs to the SLC25 family of mitochondrial carrier p...

    Authors: Heng-Chao Yu, Lu Bai, Liang Jin, Yu-Jia Zhang, Zi-Han Xi and De-Sheng Wang
    Citation: Cell Communication and Signaling 2025 23:130
    Content type: Research Published on:

  4. One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, addi...

    Authors: Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou…
    Citation: Cell Communication and Signaling 2025 23:47
    Content type: Research Published on:

  6. Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such a...

    Authors: Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao and Lihua Qu
    Citation: Cell Communication and Signaling 2025 23:24
    Content type: Review Published on:

  7. Osteosarcoma (OSA), the most common primary bone malignancy, poses significant challenges due to its aggressive nature and propensity for metastasis, especially in adolescents. Mitophagy analysis can help iden...

    Authors: Sikuan Zheng, Mengliang Luo, Hong Huang, Xuanxuan Huang, Zhidong Peng, Shaowei Zheng and Jianye Tan
    Citation: Cell Communication and Signaling 2024 22:592
    Content type: Research Published on:

  8. Alveolar type II (ATII) cells have a stem cell potential in the adult lung and repair the epithelium after injury induced by harmful factors. Their damage contributes to emphysema development, characterized by...

    Authors: Hannah Simborio, Hassan Hayek, Beata Kosmider, John W. Elrod, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner and Karim Bahmed
    Citation: Cell Communication and Signaling 2024 22:562
    Content type: Research Published on:

  9. High levels of thyroid hormones are linked to increased risk and advanced stages of breast cancer. Our previous work demonstrated that the biologically active triiodothyronine (T3) facilitates mitochondrial AT...

    Authors: Ines Tawfik, Katharina Schlick, Julian Ostaku, Doruntina Bresilla, Sonja Gabrijelčič, Benjamin Gottschalk, Alwin Sokolowski, Ernst Malle, Katarina Kalinova, Martin Hirtl and Corina T. Madreiter-Sokolowski
    Citation: Cell Communication and Signaling 2024 22:533
    Content type: Research Published on:

  11. As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effe...

    Authors: Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Meina Wang, Chong Chen, Liang Wang and Jing Liu
    Citation: Cell Communication and Signaling 2024 22:487
    Content type: Review Published on:

  12. Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to m...

    Authors: Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho and Philip Wing-Lok Ho
    Citation: Cell Communication and Signaling 2024 22:485
    Content type: Research Published on:

  13. In this study, we reported for the first time the dose-dependent dual effects of Alpha-Ketoglutarate (AKG) on cumulus oocyte complexes (COCs) during in vitro maturation (IVM). AKG at appropriate concentration ...

    Authors: Yunjie Liu, Xin Xiao, Likai Wang, Yao Fu, Songyang Yao, Xuening Liu, Boda Chen, Jiarui Gao, Yaying Zhai, Zixia Shen, Laiqing Yan, Yiwei Wang, Pengyun Ji, Bingyuan Wang and Guoshi Liu
    Citation: Cell Communication and Signaling 2024 22:472
    Content type: Research Published on:

  14. Gasdermin D (GSDMD) mediated pyroptosis plays a significant role in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. However, the precise mechanisms regulating pyroptosis remain unclear. In...

    Authors: Wenjing Sun, Hongquan Lu, Lingkun Ma, Cong Ding, Hailan Wang and Yingjie Chu
    Citation: Cell Communication and Signaling 2024 22:466
    Content type: Research Published on:

  15. Mitochondrial activity directs neuronal differentiation dynamics during brain development. In this context, the long-established metabolic coupling of mitochondria and the eukaryotic host falls short of a sati...

    Authors: Filip Vujovic, Mary Simonian, William E. Hughes, Claire E. Shepherd, Neil Hunter and Ramin M. Farahani
    Citation: Cell Communication and Signaling 2024 22:450
    Content type: Research Published on:

  16. The 2019 outbreak of SARS-CoV-2 has caused a major worldwide health crisis with high rates of morbidity and death. Interestingly, it has also been linked to cancer, which begs the issue of whether it plays a r...

    Authors: Aishwarya Jaiswal, Sanah Shrivastav, Hemant R. Kushwaha, Rupesh Chaturvedi and Rana P. Singh
    Citation: Cell Communication and Signaling 2024 22:447
    Content type: Review Published on:

  17. Mitochondria-targeting agents, known as mitocans, are emerging as potent cancer therapeutics due to pronounced metabolic and apoptotic adaptations in the mitochondria of cancer cells. ONC212, an imipridone-fam...

    Authors: Vishal Basu, Shabnam, Yamini Murghai, Maqsood Ali, Swetangini Sahu, Bhupendra K. Verma and Mahendra Seervi
    Citation: Cell Communication and Signaling 2024 22:441
    Content type: Research Published on:

  18. Dysregulation of iron metabolism is implicated in malignant transformation, cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory protein 2 (IRP2) preferentially regulates i...

    Authors: Jieon Hwang, Areum Park, Chinwoo Kim, Chang Gon Kim, Jaesung Kwak, Byungil Kim, Hyunjin Shin, Minhee Ku, Jaemoon Yang, Ayoung Baek, Jiwon Choi, Hocheol Lim, Kyoung Tai No, Xianghua Zhao, Uyeong Choi, Tae Il Kim…
    Citation: Cell Communication and Signaling 2024 22:412
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2024 22:480

  19. Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the di...

    Authors: Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu and Ruitai Fan
    Citation: Cell Communication and Signaling 2024 22:379
    Content type: Review Published on:

  21. Neurodegenerative diseases are increasingly recognized for their association with oxidative stress, which leads to progressive dysfunction and loss of neurons, manifesting in cognitive and motor impairments. T...

    Authors: Mei-Hua Jin, Lin Feng, Hong-Yi Xiang, Hu-Nan Sun, Ying-Hao Han and Taeho Kwon
    Citation: Cell Communication and Signaling 2024 22:231
    Content type: Research Published on:

About the Collection

Mitochondria regulate many essential biological processes, including apoptosis and programmed necrosis, metabolism and energetics, and cellular signaling. Deregulation of mitochondrial function has been associated with pathobiology and a growing number of human diseases.
An International Conference on “Biology Beyond Boundaries: Mitochondrial Insights, Computational Breakthroughs, and Clinical Transformations” will highlight recent advances in mitochondrial biology in an interdisciplinary forum, focusing on basic biology and diseases that include cancer and neurodegeneration. As an extension to this meeting, we invite submission to this Collection in Cell Communication and Signaling related to major themes in mitochondrial biology that include; mitochondrial stress response, mitochondrial dynamics, mitochondrial respiration and metabolism, mitochondrial biogenesis, and mitochondrial membrane permeabilization. We also welcome submissions that focus on mitochondrial and cell death pathways, cell death and immunity, and cancer therapeutics.
This Collection will aim to enhance our current understanding of mitochondrial biology, as well as exploit translational and therapeutic utilities.

Submission Guidelines

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This Collection welcomes submission of original research articles and reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Biology Beyond Boundaries: Mitochondrial and Cell Death in Translational Research" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.