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Hypertension, preeclampsia, renal and cardiovascular disease in pregnancy

This collection in Biology of Sex Differences, featuring original research and short review articles, focuses on associative, mechanistic, and translational studies linking pregnancy, pregnancy hypertension, preeclampsia, renal and cardiovascular diseases as they relate to pregnancy outcomes, placental factors, development of hypertension, congenital diseases and adverse fetal outcomes. The editors encourage submission of both basic science research using animal models and clinically relevant translational studies involving human subjects.

  1. Sex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in men’s health. Lower testosterone level is associated with cardiovascular and cardiometabolic d...

    Authors: Anil Sakamuri, Bruna Visniauskas, Isabella Kilanowski-Doroh, Alexandra B. McNally, Ariane Imulinde, Anne Kamau, Divya Sengottaian, John McLachlan, Montserrat Anguera, Franck Mauvais-Jarvis, Sarah H. Lindsey and Benard O. Ogola
    Citation: Biology of Sex Differences 2024 15:46
    Content type: Research Published on:

  2. Offspring of hypertensive disorders of pregnancy are at an increased risk of developing neurodevelopmental and neurobehavioral disorders compared to offspring from non-affected pregnancies. Using rodent models...

    Authors: Ashley Griffin, Teylor Bowles, Lucia Solis, Teryn Railey, Samer Beauti, Reanna Robinson, Shauna-Kay Spencer, James P Shaffery and Kedra Wallace
    Citation: Biology of Sex Differences 2024 15:27
    Content type: Research Published on:

  3. Preeclampsia is a multifactorial cardiovascular disorder of pregnancy. If left untreated, it can lead to severe maternal and fetal outcomes. Hence, timely diagnosis and management of preeclampsia are extremely...

    Authors: Dinara Afrose, Hao Chen, Amali Ranashinghe, Chia-chi Liu, Annemarie Henessy, Philip M. Hansbro and Lana McClements
    Citation: Biology of Sex Differences 2022 13:26
    Content type: Research Published on:

  4. Women with preeclampsia (PE) have a greater risk of developing hypertension, cardiovascular disease (CVD), and renal disease later in life. Angiotensin II type I receptor agonistic autoantibodies (AT1-AAs) are...

    Authors: George W. Booz, Daniel Kennedy, Michael Bowling, Taprieka Robinson, Daniel Azubuike, Brandon Fisher, Karen Brooks, Pooja Chinthakuntla, Ngoc H. Hoang, Jonathan P. Hosler and Mark W. Cunningham Jr.
    Citation: Biology of Sex Differences 2021 12:58
    Content type: Research Published on:

  5. Preeclampsia is a dangerous cardiovascular disorder of pregnancy that leads to an increased risk of future cardiovascular and metabolic disorders. Much of the pathogenesis and mechanisms involved in cardiac he...

    Authors: Claire Richards, Kimberly Sesperez, Michael Chhor, Sahar Ghorbanpour, Claire Rennie, Clara Liu Chung Ming, Chris Evenhuis, Valentina Nikolic, Natasa Karadzov Orlic, Zeljko Mikovic, Milan Stefanovic, Zoran Cakic, Kristine McGrath, Carmine Gentile, Kristen Bubb and Lana McClements
    Citation: Biology of Sex Differences 2021 12:31
    Content type: Research Published on:

  6. Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Mo...

    Authors: Mark W. Cunningham Jr, Lorena M. Amaral, Nathan E. Campbell, Denise C. Cornelius, Tarek Ibrahim, Venkata Ramana Vaka and Babbette LaMarca
    Citation: Biology of Sex Differences 2021 12:4
    Content type: Research Published on:

  7. The incidence of acute kidney injury (AKI) during pregnancy precedes a high maternal mortality rate of 20–40%. AKI during pregnancy has multiple etiologies; however, the more common are maternal hypertensive d...

    Authors: Jamie Szczepanski, Shauna-Kay Spencer, Ashley Griffin, Teylor Bowles, Jan Michael Williams, Patrick B. Kyle, John Polk Dumas, Sarah Araji and Kedra Wallace
    Citation: Biology of Sex Differences 2020 11:54
    Content type: Research Published on:

  8. Studies have recently examined the role of epigenetic mechanisms in preeclampsia pathophysiology. One commonly examined epigenetic process is DNA methylation. This heritable epigenetic marker is involved in ma...

    Authors: A. Cirkovic, V. Garovic, J. Milin Lazovic, O. Milicevic, M. Savic, N. Rajovic, N. Aleksic, T. Weissgerber, A. Stefanovic, D. Stanisavljevic and N. Milic
    Citation: Biology of Sex Differences 2020 11:36
    Content type: Review Published on:

  10. Since the placenta also has a sex, fetal sex–specific differences in the occurrence of placenta-mediated complications could exist.

    Authors: Zoe A. Broere-Brown, Maria C. Adank, Laura Benschop, Myrte Tielemans, Taulant Muka, Romy Gonçalves, Wichor M. Bramer, Josje D Schoufour, Trudy Voortman, Eric A. P. Steegers, Oscar H. Franco and Sarah Schalekamp-Timmermans
    Citation: Biology of Sex Differences 2020 11:26
    Content type: Review Published on:

  14. Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to t...

    Authors: Junie P. Warrington, Fan Fan, Jeremy Duncan, Mark W. Cunningham, Babette B. LaMarca, Ralf Dechend, Gerd Wallukat, Richard J. Roman, Heather A. Drummond, Joey P. Granger and Michael J. Ryan
    Citation: Biology of Sex Differences 2019 10:58
    Content type: Research Published on:

  15. Exposure to air pollution and high levels of noise have both been independently associated with the development of adverse pregnancy outcomes including low birth weight. However, exposure to such environmental...

    Authors: Colette N. Miller, Urmila P. Kodavanti, Erica J. Stewart, Mette C. Schladweiler, Judy H. Richards, Samantha J. Snow, Andres R. Henriquez, Wendy M. Oshiro, Aimen K. Farraj, Mehdi S. Hazari and Janice A. Dye
    Citation: Biology of Sex Differences 2019 10:54
    Content type: Research Published on:

  16. Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities...

    Authors: Sonja Suvakov, Hajrunisa Cubro, Wendy M. White, Yvonne S. Butler Tobah, Tracey L. Weissgerber, Kyra L. Jordan, Xiang Y. Zhu, John R. Woollard, Fouad T. Chebib, Natasa M. Milic, Joseph P. Grande, Ming Xu, Tamara Tchkonia, James L. Kirkland, Lilach O. Lerman and Vesna D. Garovic
    Citation: Biology of Sex Differences 2019 10:49
    Content type: Research Published on: