Guest Editors:
Giuseppe Paolisso, MD, University of Campania "Luigi Vanvitelli", Italy
Ronan Murphy, MD, CWSI, Dublin City University, Ireland
Marc Vanderheyden, MD, OLV Ziekenhuis, Belgium
This collection is no longer accepting submissions.
Methylation profiling of central nervous system (CNS) tumors, pioneered by the German Cancer Research Center, has significantly improved diagnostic accuracy. This study aimed to further enhance the performance...
Methylation changes linked to dilated cardiomyopathy (DCM) affect cardiac gene expression. We investigate DCM mechanisms regulated by CpG methylation using multi-omics and causal analyses in the largest cohort...
Genetic variation and modifiable risk factors play a significant role in the pathogenesis of atrial fibrillation (AF). The influence of epigenetic modification on AF remains to be elucidated. We investigated t...
Telomere length (TL) serves as a pivotal gauge of cellular aging, with shorter TL linked to various age-related ailments. Recently, a DNA methylation-based TL estimator, known as DNAmTL, has emerged as a novel...
The gut microbiota (GM) plays a critical role in regulating human physiology, with dysbiosis linked to various diseases, including heart failure (HF). HF is a complex syndrome with a significant global health ...
The role of epigenetics in cardiovascular diseases has paved the way for innovative therapeutic approaches. Investigating epigenetic changes using cell-free DNA (cfDNA) holds substantial promise beyond mere di...
As the global use of extracorporeal membrane oxygenation (ECMO) treatment increases, survival rates have not correspondingly improved, emphasizing the need for refined patient selection to optimize resource al...
Cardiac fibrosis is the hallmark of all forms of chronic heart disease. Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and infla...
The relationship between periodontitis and cardiovascular disease (CVD) has been extensively studied, but the role of biological aging in this relationship remains poorly understood. This study is dedicated to...
Cardiovascular diseases (CVD) affect over half a billion people worldwide and are the leading cause of global deaths. In particular, due to population aging and worldwide spreading of risk factors, the prevale...
Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA methyltransferase DNMT3A gene. Typical TBRS clinical features are overgrowth, ...
Environmental exposure, medical diagnostic and therapeutic applications, and industrial utilization of radionuclides have prompted a growing focus on the risks associated with low-dose radiation (< 100 mGy). C...
The management of myocardial ischemia–reperfusion injury (MIRI) presents continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays distinct roles in various disease contexts and is h...
The Correction to this article has been published in Clinical Epigenetics 2024 16:186
Heart failure (HF) is one of the most frequent and disabling diseases, affecting around 3% of the general population. It's particularly feared as a complication of chronic and acute ischemic heart disease, arterial hypertension, hypertrophic cardiomyopathy, complicated aortic stenosis, and especially diabetes mellitus. Furthermore, with the increasing number of patients undergoing chemotherapy, the incidence of cancer treatment-related cardiac dysfunction is on a steady rise. It's important to emphasize that these conditions often arise during aging, which per se, can contribute to HF development. Traditionally, two distinct phenotypes have been identified based on the ejection fraction (EF): HFpEF and HFrEF. These phenotypes are characterized by unique clinical features and require different therapy.
Epigenetic changes can also be attributed to environmental and lifestyle factors (such as physical activity and smoking) and are involved in the aetiology and development of HF. Moreover, alterations in DNA methylation and RNA expression can be considered consequences of the diseases rather than just factors contributing to their development, thus identifying potential biomarkers for disease progression.
Epigenetic variations can be associated with altered gene expression related to inflammation and atherosclerosis development, contributing to pathological cardiac remodelling and cardiomyocyte dysfunction. More recently, the use of omics, which takes a holistic approach to genomics, combined with their bioinformatic interpretation, including the use of artificial intelligence systems, has provided new insights into the impact of epigenetics in the physiopathology of HF. These insights deserve serious consideration, especially concerning potential therapeutic implications.
Indeed, the possibility of identifying and targeting erasers, writers, and readers offers the significant advantage of acting on multiple metabolic pathways rather than just a single protein or pathway, thereby expanding the possibilities for therapeutic success.
Given all these new research possibilities, this Collection will gladly consider Original Research, Short Communications, Mini-reviews, and Review articles that address heart failure and epigenetics topics.
Image credits: andrei_r / Getty Images / iStock
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