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Cell State and Fate in Health and Disease

Edited by:

Shazib Pervaiz, MBBS, PhD, National University of Singapore, Singapore
Reshma Taneja, PhD, National University of Singapore, Singapore
Shuo-Chien Ling, PhD, National University of Singapore, Singapore

Submission Status: Open   |   Submission Deadline: 30 April 2025


Cell Communication and Signaling is calling for submissions to our Collection on Cell State and Fate in Health and Disease. In this Collection, we aim to cover areas ranging from extracellular to intracellular signaling, inter-cellular communication, genetic and epigenetic control of cell state and fate, the role of metabolic plasticity and organelle dynamics to name a few in health and disease states.

About the Collection

This Collection will be dedicated to the diverse cellular processes and signaling mechanism(s) that their crosstalk in maintaining homeostasis as well as pathological implications of deregulation.

We aim to cover areas ranging from extracellular to intracellular signaling, inter-cellular communication, genetic and epigenetic control of cell state and fate, the role of metabolic plasticity and organelle dynamics to name a few in health and disease states.

Contributions will be solicited from invited speakers attending the annual Physiology Models of Health and Disease Symposium, scheduled to be held at YLL School of Medicine, National University of Singapore, Singapore on 26th and 27th September 2025, as well as open to submissions to the Collection via the journal website.  For the latter, the editors reserve the right to decide on the suitability of the submitted work to the Collection. We anticipate a good mixture of original research and review articles.

  1. Hypoxia is a common feature of solid malignancies, including cutaneous melanoma (CM). Hypoxia-inducible factor (HIF)-1α and HIF-2α orchestrate cellular responses to hypoxia and coordinate a transcriptional pro...

    Authors: Arianna Bellazzo, Barbara Montico, Roberto Guerrieri, Francesca Colizzi, Agostino Steffan, Jerry Polesel and Elisabetta Fratta
    Citation: Cell Communication and Signaling 2025 23:177
    Content type: Review Published on:

  2. Exposure to traumatic noise triggers cochlear damage and consequently causes permanent sensorineural hearing loss. However, effective treatment strategies for noise-induced hearing loss (NIHL) are lacking. Sir...

    Authors: Yuelian Luo, Haoyang Wu, Xin Min, Yi Chen, Wenting Deng, Minjun Chen, Chuxuan Yang and Hao Xiong
    Citation: Cell Communication and Signaling 2025 23:160
    Content type: Research Published on:

  3. Autophagy is a lysosome-dependent degradation pathway for recycling intracellular materials and removing damaged organelles, and it is usually considered a prosurvival process in response to stress stimuli. Ho...

    Authors: Xiangliang Huang, Hao Yan, Zhifei Xu, Bo Yang, Peihua Luo and Qiaojun He
    Citation: Cell Communication and Signaling 2025 23:151
    Content type: Review Published on:

  4. Keloid is a typical skin fibrotic disease with unclear mechanisms and limited therapeutic options. Fibroblast-induced fibrogenesis is a crucial cause of KD. However, the types of cells involved in fibroblast f...

    Authors: Xiangguang Shi, Xueyi Xia, Yang Xiao, Ying Zhang, Yiyi Gong, Yahui Chen, Chenyi Shi, Wei Wang, Jianlan Liu, Jia Huang, Mengguo Liu, Zhuoya Xu, Yanyun Ma, Mengkun Shi, Jiucun Wang and Wenyu Wu
    Citation: Cell Communication and Signaling 2025 23:141
    Content type: Research Published on:

  5. A dysregulated inflammatory response and inflammation-associated cell death are central features of renal ischemia-reperfusion injury (IRI). PANoptosis, is a recently recognized form of inflammatory programmed...

    Authors: Shaoyong Zhuang, Fangzhou Li, Liya Wang, Zilong Lai, Dawei Li, Haoyu Wu, Jiajin Wu, Junwen Qu, Xianyun Zhang, Ming Zhang, Ruoyang Chen and Xiaodong Yuan
    Citation: Cell Communication and Signaling 2025 23:140
    Content type: Research Published on:

  7. In recent 10 years, ferroptosis has become a hot research direction in the scientific research community as a new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several stu...

    Authors: Yuqi He, Yumeng Lin, Jinfeng Song, Mingzhu Song, Xiaoxia Nie, Hong Sun, Changyun Xu, Zhongyu Han and Juan Cai
    Citation: Cell Communication and Signaling 2025 23:125
    Content type: Review Published on:

  8. Hearing loss, a major public health issue, affects 1.33 per 1,000 live births worldwide. Genetic factors contribute to over half of congenital cases, with X-linked inheritance accounting for 1–5%. POU3F4 mutation...

    Authors: Jiong Dang, Panpan Bian, Chao Chen, Chi Chen, Wenqi Shan, Luhang Cai, Yong Li, Huan Tan, Baicheng Xu, Minxin Guan and Yufen Guo
    Citation: Cell Communication and Signaling 2025 23:121
    Content type: Research Published on:

  9. Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritone...

    Authors: Fang Yu, Jia Chen, Xiaoyue Wang, Shihui Hou, Hong Li, Yaru Yao, Yani He and Kehong Chen
    Citation: Cell Communication and Signaling 2025 23:114
    Content type: Review Published on:

  10. The resolution of apoptotic cells (ACs) is crucial for wound healing and tissue remodeling and is often impaired by persistent inflammation. This study aimed to elucidate the impact of neutrophil extracellular...

    Authors: Yulin Xie, Jiaman Yang, He Zhu, Rongya Yang and Yunlong Fan
    Citation: Cell Communication and Signaling 2025 23:103
    Content type: Research Published on:

  11. Angiogenesis and osteogenesis are closely interrelated. The interaction between endothelial and bone-forming cells, such as osteoblasts, is crucial for normal bone development and repair. Juxtacrine and paracr...

    Authors: Daria Perepletchikova, Polina Kuchur, Liubov Basovich, Irina Khvorova, Arseniy Lobov, Kseniia Azarkina, Nikolay Aksenov, Svetlana Bozhkova, Vitaliy Karelkin and Anna Malashicheva
    Citation: Cell Communication and Signaling 2025 23:100
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2025 23:133

  12. Cell death within the tumor microenvironment (TME) plays a crucial role in controlling cancer by influencing the balance of tumor-specific immunity. Cancer-associated fibroblasts (CAFs) significantly contribut...

    Authors: Shinyoung Kim, Kyungwon Yang, Kiyoon Kim, Hee Ja Kim, Da Young Kim, Jeesoo Chae, Young-Ho Ahn and Jihee Lee Kang
    Citation: Cell Communication and Signaling 2025 23:98
    Content type: Research Published on:

  13. Gastric cancer (GC) is a common and frequent malignant cancer of the digestive system with a poor prognosis. In addition to common therapies such as surgical resection and chemotherapy, novel biological interv...

    Authors: Lingyun Tang, Wenjie Zhang, Teng Qi, Zhengting Jiang and Dong Tang
    Citation: Cell Communication and Signaling 2025 23:82
    Content type: Review Published on:

  14. Immunotherapy for liver cancer is used to rejuvenate tumor-infiltrating lymphocytes by modulating the immune microenvironment. Thus, early protective functions of T cell subtypes with tissue-specific residency...

    Authors: Mi-So Park, Hyeonbin Jo, Hyeree Kim, Ji Young Kim, Woong-Yang Park, Yong-Han Paik, Yeup Yoon, Wonseok Kang and Hong-Hee Won
    Citation: Cell Communication and Signaling 2025 23:80
    Content type: Research Published on:

  15. Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. The former metabolic reprogramming rapidly generates...

    Authors: Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Yi Cheng, Jianxing Ma and Siyuan Yan
    Citation: Cell Communication and Signaling 2025 23:44
    Content type: Review Published on:

  16. Autophagic activation in immune cells, gut microbiota dysbiosis, and metabolic abnormalities have been reported separately as characteristics of systemic lupus erythematosus (SLE). Elucidating the crosstalk am...

    Authors: Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu and Qingjun Pan
    Citation: Cell Communication and Signaling 2025 23:40
    Content type: Research Published on:

  17. TGF-β1 is the most abundant cytokine in bone, in which it serves as a vital factor to interdict adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, how TGF-β1 concur...

    Authors: Ying-Wen Wang and Ching-Wei Luo
    Citation: Cell Communication and Signaling 2025 23:38
    Content type: Research Published on:

  18. This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. Calcium is vital for both regulating muscle excitation–contraction cou...

    Authors: Xuexin Li, Xin Zhao, Zhengshan Qin, Jie Li, Bowen Sun and Li Liu
    Citation: Cell Communication and Signaling 2025 23:17
    Content type: Research Published on:

  19. Endothelial-mesenchymal transition (EndMT) is defined as an important process of cellular differentiation by which endothelial cells (ECs) are prone to lose their characteristics and transform into mesenchymal...

    Authors: Cheng Qian, Guanglu Dong, Chunmei Yang, Weiwei Zheng, Chongjin Zhong, Qiuhong Shen, Yin Lu and Yang Zhao
    Citation: Cell Communication and Signaling 2025 23:16
    Content type: Review Published on:

  20. Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear ap...

    Authors: Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng and Kutty Selva Nandakumar
    Citation: Cell Communication and Signaling 2025 23:14
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2025 23:33

  21. Tribbles homolog 2 (TRIB2), a pseudoserine/threonine kinase, is a member of the TRIB family. TRIB2 primarily regulates cell proliferation through its scaffold or adaptor effect on promoting the degradation of ...

    Authors: Wenkang Zhang, Mingkang Li, Minhao Zhang, Gaoliang Yan and Chengchun Tang
    Citation: Cell Communication and Signaling 2025 23:5
    Content type: Review Published on:

  22. Vacuolar-type H+-ATPase (V-ATPase) is a crucial proton pump that plays an essential role in maintaining intracellular pH homeostasis and a variety of physiological processes. This review provides an in-depth e...

    Authors: Tingting Chen, Xiaotan Lin, Shuo Lu and Bo Li
    Citation: Cell Communication and Signaling 2024 22:613
    Content type: Review Published on:

  23. It is well-known that Dendritic cells (DCs) are essential in the development of airway Th2 polarization and airway allergy (AA). The underlying mechanism is still not fully understood. The objective of this st...

    Authors: Xiwen Zhang, Haoyue Zheng, Yixuan Dong, Hanqing Zhang, Le Liu, Yuanyi Zhang, Lingzhi Xu, Bailing Xie, Lihua Mo, Yu Liu, Gui Yang, Pingchang Yang and Xiaoyu Liu
    Citation: Cell Communication and Signaling 2024 22:606
    Content type: Research Published on:

  24. One of the hallmarks of cancer is metabolic reprogramming which controls cellular homeostasis and therapy resistance. Here, we investigated the effect of momordicine-I (M-I), a key bioactive compound from Momordi...

    Authors: Debojyoty Bandyopadhyay, Ellen T. Tran, Ruchi A. Patel, Matthew A. Luetzen, Kevin Cho, Leah P. Shriver, Gary J. Patti, Mark A. Varvares, David A. Ford, Kyle S. McCommis and Ratna B. Ray
    Citation: Cell Communication and Signaling 2024 22:597
    Content type: Research Published on:

  25. The realm of hematopoietic stem cell transplantation (HSCT) has witnessed remarkable advancements in elevating the cure and survival rates for patients with both malignant and non-malignant hematologic disease...

    Authors: Jieya Luo, Yunxia Zhou, Mingyang Wang, Junan Zhang and Erlie Jiang
    Citation: Cell Communication and Signaling 2024 22:596
    Content type: Review Published on:

  26. Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by cellular swelling, membrane rupture, and subsequent discharge of cellular contents, exerting robust proinflammatory effects...

    Authors: Ya Liu, Danxia Wang, Xiang Liu, Haibin Yuan, Dan Liu, Yixiang Hu and Shipeng Ning
    Citation: Cell Communication and Signaling 2024 22:586
    Content type: Review Published on:

  27. Regulation of endoplasmic reticulum (ER) homeostasis plays a critical role in maintaining cell survival. When ER stress occurs, a network of three pathways called the unfolded protein response (UPR) is activat...

    Authors: Paulina Czechowicz, Magdalena Gebert, Sylwia Bartoszewska, Leszek Kalinowski, James F. Collawn and Rafal Bartoszewski
    Citation: Cell Communication and Signaling 2024 22:577
    Content type: Brief Report Published on:

  28. The relationship between hepatocellular carcinoma (HCC) metastasis and cancer metabolism reprogramming is becoming increasingly evident. Ubiquitin-specific protease 11 (USP11), a member of the deubiquitinating...

    Authors: Yongkang Xu, Jiayu Zeng, Kan Liu, Dan Li, Shenglan Huang, Shumin Fu, Mao Ye, Si Tao and Jianbing Wu
    Citation: Cell Communication and Signaling 2024 22:550
    Content type: Methodology Published on:

Submission Guidelines

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This Collection welcomes submissions of original research and review articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please select the appropriate Collection title “Cell State and Fate in Health and Disease" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.