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Call for papers - Cell biology of Dictyostelium

Guest Editors

Cynthia Kay Damer, PhD, Central Michigan University, USA
Robert J. Huber, PhD, Trent University, Canada
Paul Steimle, PhD, UNC Greensboro, USA

Submission Status: Open   |   Submission Deadline: 21 August 2025


BMC Molecular and Cell Biology invites researchers to contribute to the exploration of the cell biology of Dictyostelium discoideum, focusing on its role as a model organism for understanding fundamental cellular processes. This Collection welcomes submissions that investigate all aspects of Dictyostelium-related biology such as cell motility, signal transduction, and cell differentiation, aiming to enhance our knowledge of cellular behavior and its implications for health and disease.

Meet the Guest Editors

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Cynthia Kay Damer, PhD, Professor of Biology, Central Michigan University, USA

Dr Cynthia Damer is a Professor of Biology at Central Michigan University. She has a PhD in Neuroscience from the University of Virginia where she studied the protein synaptagmin involved in neurotransmitter release. As a postdoctoral fellow at Duke University, Dr Damer studied the endocytic protein clathrin using the model organism, Dictyostelium discoideum. She has been using Dictyostelium as a model to study basic cellular processes for over 25 years. Her research focuses on copines, a family of calcium-dependent lipid binding proteins. At CMU, Cynthia teaches classes in cell biology, microscopy, neuroscience, and biotechnology. 
 

Robert J. Huber, PhD, Associate Professor, Department of Biology; Director, Molecules, Cells & Systems Research Centre, Trent University, Canada

Dr Robert Huber is a cell and molecular biologist who uses Dictyostelium discoideum as a model system for studying fundamental cellular and developmental processes. Current research in his lab focuses on lysosomal function, protein trafficking and secretion, and signal transduction, with a specific focus on how these processes are dysregulated in Batten disease (a form of neurodegeneration that affects all ages and ethnicities but primarily impacts children and adolescents).
 

Paul Steimle, PhD, University of North Carolina Greensboro, USA

In his research at UNCG, Dr Steimle strives to gain further insight into how cells are able to achieve highly coordinated changes in shape that are required for critical cellular processes such as chemotaxis, cytokinesis, intracellular trafficking, and multicellular development. To this end, the social amoeba, Dictyostelium discoideum, is used as a model system for examining the molecular pathways regulating the ability of myosin II to mediate contraction of actin filaments in the highly dynamic context of a nonmuscle cell. 
 
The long term goal of his research program is to provide a clearer understanding of the molecular events driving cellular contractile processes since defects in the regulation of these events, as occur in cancer cells, can lead to uncontrolled cell multiplication (tumor formation) and unregulated cell migration observed with metastasis.

About the Collection

The social amoeba Dictyostelium discoideum exhibits remarkable behaviors, including chemotaxis and alternating its structure between unicellular and multicellular states, making it a powerful tool for studying cellular communication and development. The simplicity of its genome and its ease of genetic manipulation further enhance the utility of Dictyostelium as a model organism and have made it a cornerstone of the field of molecular and cell biology.

As research into Dictyostelium continues to progress, we anticipate substantial advances in our understanding of cellular behavior and communication. Future studies hold the potential to identify novel signaling pathways and regulatory mechanisms that govern fundamental processes like cell motility and differentiation, with potential applications ranging from developmental biology to understanding diseases involving cell movement, signaling errors, and altered protein function.

Against this backdrop, BMC Molecular and Cell Biology aims to create a Collection that highlights the most innovative new research focusing on this one-of-a-kind organism. Topics of interest include, but are not limited to:

  • Nuclear structure and function
  • Mechanisms of cell motility 
  • Signal transduction pathways and cell-to-cell communication
  • Host-pathogen interactions
  • Endocytic mechanisms and pathways
  • Lysosomes and autophagy
  • Cellular pathways involved in cell differentiation and development
  • Multicellular organization
  • Evolution of social behavior
  • Dictyostelium as a model system for human disease

Image credit: © EYE OF SCIENCE / Science Photo Library

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original Research Articles, Database articles, and Software articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Cell biology of Dictyostelium" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.