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Towards malaria elimination

The launch of a new thematic series of Malaria Journal, "Towards malaria elimination", creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic settings and conditions into the circles of scientists, public health specialists, national and global programme managers, funders and decision makers.

"Towards malaria elimination" welcomes original papers, reviews, commentaries and opinion pieces on malaria elimination and eradication, and hopes that this mix of scientific information and debate will catalyze and dynamize the move towards more intensified control and progressively malaria elimination within a spirit of mutual learning for change. The Editors very much hope that many scientists, public health professionals and policy makers will start using "Towards malaria elimination" as one of their ways to share new evidence or to discuss evidence presented in the scientific literature.

View all collections published in Malaria Journal.

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  1. This work investigated the future (2021–2050) impact of Climate Change on Malaria Prevalence in the Upper River Region of The Gambia under two representative concentration pathways, RCP4.5 and RCP8.5, comparin...

    Authors: Ugochinyere Agatha Okafor, Pierre-Claver Konin Kakou, Umberto D’Alessandro, Vincent Nduka Ojeh and Sidat Yaffa
    Citation: Malaria Journal 2025 24:108
    Content type: Research Published on:

  2. Forest-exposed populations remain the last significant, and most difficult to access, high-risk populations for malaria in Cambodia. Despite the availability of long-lasting insecticidal nets (LLINs) and/or ha...

    Authors: David J. McIver, Elodie A. Vajda, Dyna Doum, Nicholas W. Daniel, Molly Quan, Diane D. Lovin, Joanne M. Cunningham, Siv Sovannaroth, Allison Tatarsky and Neil F. Lobo
    Citation: Malaria Journal 2025 24:96
    Content type: Research Published on:

  3. Strengthening malaria control and expediting progress toward elimination requires targeting gametocytes to interrupt transmission. Artemisinin-based combination therapy (ACT) effectively clears Plasmodium falcipa...

    Authors: Kassahun Habtamu, Hallelujah Getachew, Ashenafi Abossie, Assalif Demissew, Arega Tsegaye, Teshome Degefa, Daibin Zhong, Xiaoming Wang, Ming-Chieh Lee, Guofa Zhou, Solomon Kibret, Christopher L. King, James W. Kazura, Beyene Petros, Delenasaw Yewhalaw and Guiyun Yan
    Citation: Malaria Journal 2025 24:87
    Content type: Research Published on:

  4. Assessing the acceptability of new malaria control interventions in clinical trials can be complex due to the need for strict ethical standards and specific trial procedures. While in-depth interviews and focu...

    Authors: Truphena Onyango, Khadija Nuru, Karisa Kazungu, Winnie Wangari, Carlos Chaccour, N. Regina Rabinovich, Joseph Mwangangi, Marta Maia and Caroline Jones
    Citation: Malaria Journal 2025 24:79
    Content type: Research Published on:

  5. Foreign migrant workers from malaria-endemic regions play a critical factor in the transmission of malaria to non-endemic areas, mainly due to their mobility while seeking employment opportunities. This risk i...

    Authors: Nurhadi Eko Firmansyah, Thaksaporn Thongseesuksai, Thidarut Boonmars and Porntip Laummaunwai
    Citation: Malaria Journal 2025 24:18
    Content type: Research Published on:

  6. The increased occurrence of malaria among Africa’s displaced communities poses a new humanitarian problem. Understanding malaria epidemiology among the displaced population in African refugee camps is a vital ...

    Authors: Habtu Debash, Ermiyas Alemayehu, Melaku Ashagrie Belete, Hussen Ebrahim, Ousman Mohammed, Daniel Gebretsadik, Mihret Tilahun and Alemu Gedefie
    Citation: Malaria Journal 2025 24:15
    Content type: Research Published on:

  7. Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities ...

    Authors: Olivier Sibomana, John Bukuru, Sulymon A. Saka, Marie Grace Uwizeyimana, Alex Mwangi Kihunyu, Abraham Obianke, Samuel Oluwo Damilare, Lewis Tem Bueh, Beloved of God Agbelemoge and Richard Omoefe Oveh
    Citation: Malaria Journal 2025 24:1
    Content type: Review Published on:

  8. Ethiopia has been progressing very well in controlling malaria in the past few years. However, shortly after the COVID-19 pandemic, an unpredictable malaria resurgence was observed in almost all malaria-endemi...

    Authors: Aster Alemu, Beshada Lemma, Temesgen Bekele, Geleta Geshere, Eba Alemayehu Simma, Chernet Tuge Deressa and Tsige Ketema
    Citation: Malaria Journal 2024 23:397
    Content type: Research Published on:

  9. Malaria remains a significant public health concern, despite global efforts to combat the disease with highest burden in Africa. Reports of emerging artemisinin partial- resistance in East Africa emphasize the...

    Authors: Paulina Tindana, Daniel Enos Sekwo, Leonard Baatiema and Abdoulaye Djimde
    Citation: Malaria Journal 2024 23:385
    Content type: Research Published on:

  10. Larval source management (LSM) effectively reduces mosquito populations at their breeding sites, addressing issues like insecticide resistance that limit the effectiveness of primary interventions such as inse...

    Authors: Najat F. Kahamba, Felista S. Tarimo, Khamisi Kifungo, Winifrida Mponzi, Siaba A. Kinunda, Alfred Simfukwe, Salum Mapua, Betwel Msugupakulya, Francesco Baldini, Heather M. Ferguson, Fredros O. Okumu and Marceline F. Finda
    Citation: Malaria Journal 2024 23:336
    Content type: Research Published on:

  11. In 2021, an estimated 750,000 people died from malaria. Despite this significant burden, globally, malaria incidence and mortality rates have substantially dropped over the last 30 years. However, growth in sp...

    Authors: Angela E. Apeagyei, Ian Cogswell, Nishali K. Patel, Kevin O’Rourke, Golsum Tsakalos and Joseph L. Dieleman
    Citation: Malaria Journal 2024 23:333
    Content type: Research Published on:

  12. Malaria remains a significant global health challenge, with millions of cases and high mortality rates annually, especially in low-income countries. Africa bears a substantial burden, with direct costs of mala...

    Authors: Stanley Eneh, Francisca Onukansi, Ogechi Ikhuoria and Temitope Ojo
    Citation: Malaria Journal 2024 23:325
    Content type: Perspective Published on:

  13. Malaria is an infectious disease caused by the Plasmodium species and is a global burden. When not treated correctly, it can reemerge as a relapse or recrudescence. Malaria relapse cases can contribute to maintai...

    Authors: Klauss Kleydmann Sabino Garcia, Karina Medeiros de Deus Henriques, Antonio Alcirley da Silva Balieiro, Anielle de Pina-Costa and André M. Siqueira
    Citation: Malaria Journal 2024 23:312
    Content type: Research Published on:

  14. Healthcare providers (HCPs) practice and correct management of suspected malaria (CMSM) are central components of malaria elimination and prevention of re-establishment (POR) in countries in the elimination ph...

    Authors: Reza Majdzadeh, Mohammad Ali Mansournia, Ayat Ahmadi, Ahmad Raeisi and Hosein Azizi
    Citation: Malaria Journal 2024 23:307
    Content type: Research Published on:

  16. The emergence of Plasmodium falciparum drug resistance against artemisinin-based combination therapy has threatened malaria control efforts. Since malaria control and elimination plans are dependent on these drug...

    Authors: Dagmawi Woldesenbet, Meseret Birhanie, Aberham Abere, Ayalew Jejaw Zeleke, Migbaru Keffale Bezabih, Muluken Semaw, Menberu Wubetie, Wagaw Abebe, Elias Tamene and Yalewayker Tegegne
    Citation: Malaria Journal 2024 23:266
    Content type: Research Published on:

  18. Nigeria has the highest malaria burden globally, and anti-malarials have been commonly used to treat malaria without parasitological confirmation. In 2012, Nigeria implemented rapid diagnostic tests (RDTs) to ...

    Authors: Sandra C. Olisakwe, Julie Thwing, Jodie A. Dionne, Ryan Irvin, Patrick S. Kachur and Katia J. Bruxvoort
    Citation: Malaria Journal 2024 23:249
    Content type: Research Published on:

  19. Ghana is a malaria-endemic country with the entire population at risk. The Northern region of the country recorded the highest malaria case fatality rate (CFR) for two consecutive years: 1.11% in 2013 and 1.07...

    Authors: Nana Yaw Peprah, Wahjib Mohammed, George Asumah Adu, Dora Dadzie, Sammy Oppong, Seidu Barikisu, Joel Narh, Stephen Appiah, James Frimpong and Keziah L. Malm
    Citation: Malaria Journal 2024 23:230
    Content type: Research Published on:

  20. Biological control is a promising alternative or complementary approach for controlling vector populations in response to the spread of insecticide resistance in malaria vectors. This study evaluated the effic...

    Authors: Herieth H. Mahenge, Letus L. Muyaga, Joel D. Nkya, Andrew D. Kafwenji, Yohana A. Mwalugelo, Najat F. Kahamba, Halfan S. Ngowo and Emmanuel W. Kaindoa
    Citation: Malaria Journal 2024 23:228
    Content type: Research Published on:

  21. Thailand aimed to eliminate malaria by 2024, and as such is planning for future prevention of re-establishment in malaria free provinces. Understanding the receptivity of local areas to malaria allows the appr...

    Authors: Rebecca Walshe, Kulchada Pongsoipetch, Suwanna Mukem, Tanong Kamsri, Navarat Singkham, Prayuth Sudathip, Suravadee Kitchakarn, Rapeephan Rattanawongnara Maude and Richard James Maude
    Citation: Malaria Journal 2024 23:224
    Content type: Research Published on:

  22. Malaria remains a global health challenge, particularly in Peru's Loreto region. Despite ongoing efforts, high infection rates and asymptomatic cases perpetuate transmission. The Peruvian Ministry of Health’s ...

    Authors: Viviana Pinedo-Cancino, Katty M. Arista, G. Christian Baldeviano, Rafael Saavedra-Langer, Andrei Arana, Maria E. Vásquez-Chasnamote, Andree Valle-Campos, Juan C. Castro, Julio A. Ventocilla, Edward S. Smith, Andres G. Lescano and Lastenia Ruíz-Mesia
    Citation: Malaria Journal 2024 23:209
    Content type: Research Published on:

  23. While substantial gains have been made in the fight against malaria over the past 20 years, malaria morbidity and mortality are marked by inequality. The equitable elimination of malaria within countries will ...

    Authors: Angela E. Apeagyei, Nishali K. Patel, Ian Cogswell, Kevin O’Rourke, Golsum Tsakalos and Joseph Dieleman
    Citation: Malaria Journal 2024 23:206
    Content type: Research Published on:

    The Publisher Correction to this article has been published in Malaria Journal 2024 23:248

  24. Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of...

    Authors: Beka R. Abagero, Rei Rama, Abdulghani Obeid, Tirusew Tolosa, Biniyam Lukas, Taye Teka, Daniel Tesfaye, Eugenia Lo and Delenasaw Yewhalaw
    Citation: Malaria Journal 2024 23:194
    Content type: Research Published on:

  26. With only one 15 mg primaquine tablet registered by a stringent regulatory authority and marketed, more quality-assured primaquine is needed to meet the demands of malaria elimination.

    Authors: Julie Nguyen Ngoc Pouplin, Thoopmanee Kaendiao, Bilal Ahmad Rahimi, Mayur Soni, Hensi Basopia, Darshana Shah, Jitendra Patil, Vyom Dholakia, Yash Suthar, Joel Tarning, Mavuto Mukaka and Walter R. Taylor
    Citation: Malaria Journal 2024 23:176
    Content type: Research Published on:

  27. National Malaria Programmes (NMPs) monitor the durability of insecticide-treated nets (ITNs) to inform procurement and replacement decisions. This is crucial for new dual active ingredients (AI) ITNs, for whic...

    Authors: Jacky Raharinjatovo, Roch Kounbobr Dabiré, Keith Esch, Dieudonné Diloma Soma, Aristide Hien, Tiecoura Camara, Mame Birame Diouf, Allison Belemvire, Lilia Gerberg, Taiwo Samson Awolola, Adama Koné, Djenam Jacob, Sophie Vandecandelaere, Marie Baes and Stephen Poyer
    Citation: Malaria Journal 2024 23:173
    Content type: Research Published on:

  28. Mexico has experienced a significant reduction in malaria cases over the past two decades. Certification of localities as malaria-free areas (MFAs) has been proposed as a steppingstone before elimination is ac...

    Authors: Denis Escobar, Gabriela González-Olvera, Ángel S. Gómez-Rivera, Juan Navarrete-Carballo, Pedro Mis-Ávila, Raquel Baack-Valle, Guillermo Escalante, Gerardo Reyes-Cabrera, Fabian Correa-Morales, Azael Che-Mendoza, Gonzalo Vazquez-Prokopec, Audrey Lenhart and Pablo Manrique-Saide
    Citation: Malaria Journal 2024 23:165
    Content type: Research Published on:

  29. Malaria is a major public health concern in Ethiopia, where more than half of the population lives in malaria risk areas. While several studies have been conducted in different eco-epidemiological settings in ...

    Authors: Kinfu Boresa, Tariku Belay, Abdissa Biruksew, Eshetu Alemayehu and Endalew Zemene
    Citation: Malaria Journal 2024 23:152
    Content type: Research Published on:

  30. Despite continuous prevention and control strategies in place, malaria remains a major public health problem in sub-Saharan Africa including Ethiopia. Moreover, prevalence of malaria differs in different geogr...

    Authors: Girma Yutura, Fekadu Massebo, Nigatu Eligo, Abena Kochora and Teklu Wegayehu
    Citation: Malaria Journal 2024 23:143
    Content type: Research Published on:

  31. In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission...

    Authors: Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey and Deus S. Ishengoma
    Citation: Malaria Journal 2024 23:139
    Content type: Research Published on:

  33. There are giant steps taken in the introduction of the novel malaria vaccine poised towards reducing mortality and morbidity associated with malaria.

    Authors: Awoere T. Chinawa, Edmund N. Ossai, Vivian O. Onukwuli, Obinna C. Nduagubam, Ndubuisi A. Uwaezuoke, Chinyere N. Okafor and Josephat M. Chinawa
    Citation: Malaria Journal 2024 23:117
    Content type: Research Published on:

  34. Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasm...

    Authors: Bacha Mekonen, Sisay Dugassa, Sindew Mekasha Feleke, Boja Dufera, Bedasa Gidisa, Aderaw Adamu, Aynalem Mandefro, Geremew Tasew and Lemu Golassa
    Citation: Malaria Journal 2024 23:108
    Content type: Research Published on:

  35. In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic diversit...

    Authors: Alex Mwesigwa, Moses Ocan, Benson Musinguzi, Rachel Wangi Nante, Joaniter I. Nankabirwa, Steven M. Kiwuwa, Alison Annet Kinengyere, Barbara Castelnuovo, Charles Karamagi, Ekwaro A. Obuku, Samuel L. Nsobya, Sam M. Mbulaiteye and Pauline Byakika-Kibwika
    Citation: Malaria Journal 2024 23:97
    Content type: Review Published on:

  36. Malaria remains a public health problem in regions of Northeastern India because of favourable bio-geographic transmission conditions, poor access to routine healthcare, and inadequate infrastructure for publi...

    Authors: Carinthia B. Nengnong, Mattimi Passah, Mark L. Wilson, Elisa Bellotti, Anne Kessler, Bibha R. Marak, Jane M. Carlton, Rajiv Sarkar and Sandra Albert
    Citation: Malaria Journal 2024 23:83
    Content type: Research Published on:

  37. Vegetation health (VH) is a powerful characteristic for forecasting malaria incidence in regions where the disease is prevalent. This study aims to determine how vegetation health affects the prevalence of mal...

    Authors: Gouvidé Jean Gbaguidi, Mouhamed Idrissou, Nikita Topanou, Walter Leal Filho and Guillaume K. Ketoh
    Citation: Malaria Journal 2024 23:78
    Content type: Research Published on:

  38. Pyrethroid-based indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) have been employed as key vector control measures against malaria in Namibia. However, pyrethroid resistance in Anopheles

    Authors: Rosalia N. Joseph, Tabeth Mwema, Seth J. Eiseb, Deodatus V. Maliti, Munyaradzi Tambo, Iitula Iitula, Lydia Eloff, Ophilia Lukubwe, Cara Smith-Gueye, Élodie A. Vajda, Allison Tatarsky, Stark T. Katokele, Petrina N. Uusiku, Dennis Walusimbi, Sheila B. Ogoma, Davis R. Mumbengegwi…
    Citation: Malaria Journal 2024 23:77
    Content type: Research Published on:

  39. Genetic surveillance of the Plasmodium falciparum parasite shows great promise for helping National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polyge...

    Authors: Wesley Wong, Stephen F. Schaffner, Julie Thwing, Mame Cheikh Seck, Jules Gomis, Younouss Diedhiou, Ngayo Sy, Medoune Ndiop, Fatou Ba, Ibrahima Diallo, Doudou Sene, Mamadou Alpha Diallo, Yaye Die Ndiaye, Mouhamad Sy, Aita Sene, Djiby Sow…
    Citation: Malaria Journal 2024 23:68
    Content type: Research Published on:

  40. The malaria incidence data from a malaria prevention study from the Rift Valley, Central Ethiopia, were reanalysed. The objective was to investigate whether including an administrative structure within the soc...

    Authors: Taye Gari and Bernt Lindtjørn
    Citation: Malaria Journal 2024 23:67
    Content type: Research Published on:

  41. Malaria elimination requires closely co-ordinated action between neighbouring countries. In Southern Africa several countries have reduced malaria to low levels, but the goal of elimination has eluded them thu...

    Authors: Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa and Immo Kleinschmidt
    Citation: Malaria Journal 2024 23:62
    Content type: Case Study Published on:

    The Correction to this article has been published in Malaria Journal 2024 23:98

  42. By 2022, the Government of Indonesia had successfully eliminated malaria in 389 out of 514 districts but continues to face a challenge in Eastern Indonesia where 95% of the total 2021 malaria cases were report...

    Authors: Dee Jupp, Sherria Ayuandini, Frisca Tobing, Denny Halim, Enny Kenangalem, Maria E. Sumiwi, Hellen D. Prameswari, Minerva Theodora, Hermawan Susanto, Riskha T. P. Dewi, Dedy Supriyanto, Bayu Kurnia, Mrunal Shetye, Ermi Ndoen and Yuka Onishi
    Citation: Malaria Journal 2024 23:59
    Content type: Research Published on:

  43. Gabon still bears significant malaria burden despite numerous efforts. To reduce this burden, policy-makers need strategies to design effective interventions. Besides, malaria distribution is well known to be ...

    Authors: Fabrice Mougeni, Bertrand Lell, Ngianga-Bakwin Kandala and Tobias Chirwa
    Citation: Malaria Journal 2024 23:57
    Content type: Research Published on:

  44. Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over the last two decades. Successful implementation of MDA programmes requires community participation and can be threa...

    Authors: Christian Kositz, Hristina Vasileva, Nuredin Mohammed, Jane Achan, Edgard Diniba Dabira, Umberto D’Alessandro, John Bradley and Michael Marks
    Citation: Malaria Journal 2024 23:54
    Content type: Research Published on:

  46. Malaria remains an enduring public health concern in Indonesia, exacerbated by its equatorial climate that fosters the proliferation of Anopheles mosquitoes. This study seeks to assess the performance of the mala...

    Authors: Hamzah Hasyim, Heni Marini, Misnaniarti Misnaniarti, Rostika Flora, Iche Andriyani Liberty, Ahmed Elagali, Hartoni Hartoni and Fadhilah Eka Maharani
    Citation: Malaria Journal 2024 23:43
    Content type: Research Published on:

  47. The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this resid...

    Authors: Lepa Syahrani, Puji B. S. Asih, Anom Bowolaksono, Astari Dwiranti, Siti Zubaidah, Ismail E. Rozi, Dendi H. Permana, Claus Bøgh, Michael J. Bangs, John P. Grieco, Nicole L. Achee, Neil F. Lobo and Din Syafruddin
    Citation: Malaria Journal 2024 23:31
    Content type: Research Published on:

  48. Malaria remains a significant public health concern in Niger, with the number of cases increasing from 592,334 in 2000 to 3,138,696 in 2010. In response, a concerted campaign against the disease has been initi...

    Authors: Ali Issakou Malam Tchole, Run-Ze Ye, Qing Xu, Zhen-Wei Li, Jin-Yue Liu, Shan-Shan Wang, Jing Liu, Xiao-Yang Wang, Alassan Maman Bachir, Lin Zhao and Wu-Chun Cao
    Citation: Malaria Journal 2024 23:30
    Content type: Research Published on:

  49. Malaria outbreaks are detected by applying the World Health Organization (WHO)-recommended thresholds (the less sensitive 75th percentile or mean + 2 standard deviations [2SD] for medium-to high-transmission a...

    Authors: Marie Gorreti Zalwango, Jane F. Zalwango, Daniel Kadobera, Lilian Bulage, Carol Nanziri, Richard Migisha, Bosco B. Agaba, Benon Kwesiga, Jimmy Opigo, Alex Riolexus Ario and Julie R. Harris
    Citation: Malaria Journal 2024 23:18
    Content type: Research Published on:

  50. Approximately 32 million pregnant women are at risk of malaria with up to 10,000 maternal deaths and 200,000 neonates at risk annually. Intermittent Preventive Treatment (IPT) with sulfadoxine-pyrimethamine (S...

    Authors: Sabrina Lynda Simo Kamga, Innocent Mbulli Ali, Ghislain Romeo Ngangnang, Mehmet Can Ulucesme, Leonard T. D. Keptcheu, Eva Mai Keming, Valery-Pacome Kom Tchuenkam, Juluis Visnel Foyet, Münir Aktas, Michel Noubom and Vincent K. Payne
    Citation: Malaria Journal 2024 23:6
    Content type: Research Published on: