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Mechanisms and Etiology of Male Health Disorders: Hormones, Cancer, and Fertility

Edited by:

Marco Cordani, PhD, Complutense University of Madrid, Spain
Ilaria Dando, PhD, University of Verona, Italy
Giulia Ambrosini, PhD, University of Verona, Italy
Pedro González-Menéndez, PhD, University of Oviedo, Spain

Submission Status: Closed  

This collection is no longer accepting submissions.












Cell Communication and Signaling is calling for submissions to our Collection on Mechanisms and Etiology of Male Health Disorders: Hormones, Cancer, and Fertility. We invite papers that elucidate novel cell signaling pathways and mechanisms of action, as well as papers that address therapeutic strategies that target disease processes.

New Content ItemThis Collection supports and amplifies research related to SDG 3: Good Health and Well-being

  1. Aging is associated with a reduction in skeletal muscle fiber size and number, leading to a decline in physical function and structural integrity—a condition known as sarcopenia. This syndrome is further chara...

    Authors: Gentile Giulia°, De Stefano Ferdinando°, Sorrentino Carmela, D’Angiolo Rosa, Lauretta Carmine, Giovannelli Pia, Migliaccio Antimo, Castoria Gabriella and Di Donato Marzia
    Citation: Cell Communication and Signaling 2025 23:167
    Content type: Review Published on:

  2. Stress granules (SGs) are conserved messenger ribonucleoprotein (mRNP) granules that form through rapid coalescence in the cytoplasm of eukaryotic cells under stressful environments. These dynamic membrane-fre...

    Authors: Jiaxin Li, Linyuan Shen, Kai Wang, Shuang Wu, Yan Wang, Yuheng Pan, Siyu Chen, Ting Zhao, Ye Zhao, Lili Niu, Lei Chen, Shunhua Zhang, Li Zhu and Mailin Gan
    Citation: Cell Communication and Signaling 2025 23:84
    Content type: Review Published on:

  3. Prostate cancer (PrCa) is a significant health concern, ranking as the second most common cancer in males globally. Genetic factors contribute substantially to PrCa risk, with up to 57% of the risk being attri...

    Authors: Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä and Johanna Schleutker
    Citation: Cell Communication and Signaling 2025 23:71
    Content type: Research Published on:

  4. Sex determination mechanisms vary significantly across different chromosomal systems and evolutionary contexts. Nonetheless, the regulatory framework governing the multi-sex chromosome system (X1X1X2X2/X1X2Y) rem...

    Authors: Haixia Zhao, Jun Li, Zhizhong Xiao and Yongshuang Xiao
    Citation: Cell Communication and Signaling 2025 23:59
    Content type: Research Published on:

  5. Ionizing radiation (IR) poses a significant threat to male fertility by inducing substantial changes in the testis, yet the mechanisms underlying IR-induced spermatogenesis disorders remain poorly understood, ...

    Authors: Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen and Xinyi Xia
    Citation: Cell Communication and Signaling 2025 23:58
    Content type: Research Published on:

  6. Asthenozoospermia (ASZ) accounts for about 20-40% of male infertility, and genetic factors, contributing to 30-40% of the causes of ASZ, still need further exploration. Radial spokes (RSs), a T-shaped macromol...

    Authors: Tingwenyi Hu, Xiangrong Tang, Tiechao Ruan, Shunhua Long, Guicen Liu, Jing Ma, Xueqi Li, Ruoxuan Zhang, Guoning Huang, Ying Shen and Tingting Lin
    Citation: Cell Communication and Signaling 2025 23:41
    Content type: Research Published on:

  7. Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed ...

    Authors: Andrea Errico, Giulia Ambrosini, Sara Vinco, Emanuela Bottani, Elisa Dalla Pozza, Nunzio Marroncelli, Jessica Brandi, Daniela Cecconi, Ilaria Decimo, Filippo Migliorini, Nicola Zampieri and Ilaria Dando
    Citation: Cell Communication and Signaling 2025 23:19
    Content type: Research Published on:

  8. Cryopreservation of bull sperm, crucial for breeding and assisted reproduction, often reduces sperm quality due to oxidative stress. This study examines how oxidative stress during cryopreservation affects per...

    Authors: Mostek-Majewska Agnieszka, Bossowska-Nowicka Magdalena, Słowińska Mariola and Ciereszko Andrzej
    Citation: Cell Communication and Signaling 2025 23:15
    Content type: Research Published on:

  9. Advanced prostate cancer (PCa) often initially responds to androgen receptor signaling inhibitors (ARSI) but frequently develops resistance, driven by tumor heterogeneity and therapeutic pressure. Addressing t...

    Authors: Chuanfan Zhong, Jiaxing Wang, Hangyang Peng, Jianming Lu, Zining Long, Zhuoyuan Lin, Guo Chen, Chao Cai, Shilong Cheng, Zhongjie Chen, Le Zhang, Weibo Zhong, Rujun Mo and Xiangming Mao
    Citation: Cell Communication and Signaling 2024 22:600
    Content type: Research Published on:

  10. In cases of advanced seminoma, up to 30% of patients may manifest cisplatin resistance, necessitating aggressive salvage therapy, with a consequent 50% risk of mortality attributable to cancer. Nevertheless, b...

    Authors: Yankang Cui, Xiaodie Zhou, Jing Zhang, Bo Fang, Jingping Ge, Hao Tang, Bianjiang Liu, Haowei He, Feng Xu and Xuejun Shang
    Citation: Cell Communication and Signaling 2024 22:560
    Content type: Research Published on:

  11. Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternativ...

    Authors: Doha Shokry, Mehwish W. Khan, Christine Powell, Samantha Johnson, Brayden C. Rennels, Raya I. Boyd, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Maryanna H. Parker, Miranda D. Vieson, Jonathan P. Samuelson, Michael J. Spinella and Ratnakar Singh
    Citation: Cell Communication and Signaling 2024 22:528
    Content type: Research Published on:

  12. Septins are a family of cytokinesis-related proteins involved in regulating cytoskeletal design, cell morphology, and tissue morphogenesis. Apart from cytokinesis, as a fourth component of cytoskeleton, septin...

    Authors: Hana Al-Ali, Amna Baig, Rayyah R. Alkhanjari, Zoha F. Murtaza, Maitha M. Alhajeri, Rawdah Elbahrawi, Azhar Abdukadir, Poorna Manasa Bhamidimarri, Junaid Kashir and Hamdan Hamdan
    Citation: Cell Communication and Signaling 2024 22:523
    Content type: Review Published on:

  13. Prostate cancer is among prevalent cancers in men. Numerous strategies have been proposed to intervene with the important prostate cancer-related signaling pathways. Among the most promising strategies is CRIS...

    Authors: Mobina Tabibian, Fahimeh Salasar Moghaddam, Elahe Motevaseli and Soudeh Ghafouri-Fard
    Citation: Cell Communication and Signaling 2024 22:504
    Content type: Review Published on:

  14. Androgens are essential hormones for testicular development and the maintenance of male fertility. Environmental factors, stress, aging, and psychological conditions can disrupt androgen production, impacting ...

    Authors: Wenhui Zhai, Hairui Tian, Xuemei Liang, Yunqiang Wu, Jian Wen, Zhipeng Liu, Xiaodong Zhao, Li Tao and Kang Zou
    Citation: Cell Communication and Signaling 2024 22:498
    Content type: Research Published on:

  15. C-X-C receptor 4(CXCR4) is widely considered to be a highly conserved G protein-coupled receptor, widely involved in the pathophysiological processes in the human body, including fibrosis. However, its role in...

    Authors: Yi Zhang, Chen Zhang, Rui Feng, Tong Meng, Wei Peng, Jian Song, Wenming Ma, Wenlong Xu, Xianguo Chen, Jing Chen and Chaozhao Liang
    Citation: Cell Communication and Signaling 2024 22:456
    Content type: Research Published on:

About the Collection

Normal male physiology is governed by a variety of homestatic factors that include hormonal signaling, aging and environmental factors, genetic and epigenetic influences, as well as regulated inter- and intra-cellular communications that affect cellular functions and gene expression. Many of the aforementioned processes go array in diseases that affect male health.

In this Collection, we call for original research and review articles that focus on the etiology and pathogenesis of male diseases at the molecular and cellular level.

Topics include, but not limited to, male cancers, hormonal signaling pathways, how male hormones and growth factors influence HPA axis, testicular function, and spermatogenesis, and genetics.

We invite papers that elucidate novel cell signaling pathways and mechanisms of action, as well as papers that address therapeutic strategies that target disease processes.

Our aim is to shed light on emerging themes in this research area highlighting discoveries that enrich our understanding of male diseases.

Submission Guidelines

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This Collection welcomes submissions of original research and review articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal.

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Mechanisms and Etiology of Male Health Disorders: Hormones, Cancer, and Fertility" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.