X. William Yang, MD, PhD, University of California, Los Angeles, United States
Li Gan, PhD, Weill Cornell Medical College, United States
Image credit: © nobeastsofierce / stock.adobe.com
X. William Yang, MD, PhD, University of California, Los Angeles, United States
Li Gan, PhD, Weill Cornell Medical College, United States
The review series will feature contributions from leading experts in the field, each focusing on pivotal aspects of neuroimmune interactions in neurodegeneration. Topics will include the role of complement systems in Alzheimer's Disease (AD), highlighting how these immune proteins contribute to neuronal damage and disease progression, and the systems biology of neuroimmune contributions to AD, providing a comprehensive analysis of how systemic immune responses can influence neural integrity. Additionally, the critical interplay between metabolic reprogramming and microglia in AD will be examined, offering insights into how metabolic shifts in these immune cells impact neurodegenerative processes. Further topics will explore the role of brain vasculature cell types and their contributions to neurodegenerative diseases, shedding light on the vascular dimension of neuroimmune dysregulation. The involvement of the inflammasome in AD will be investigated, examining how this intracellular complex drives chronic inflammation and neuronal death. Last but not least, genetic evidence for resilient pathways against Alzheimer's will be reviewed, identifying genetic variants that confer protection and resilience against neurodegeneration.
By bringing together these diverse but interconnected perspectives, this review series aims to catalyze new research directions and therapeutic strategies. It is our hope that these comprehensive reviews will not only enhance our understanding of neuroimmune dysregulation in neurodegenerative diseases but also pave the way for novel interventions that can mitigate the devastating impacts of these conditions.
Together, we strive to push the boundaries of knowledge and transform our understanding of how neuroimmune processes influence neurodegeneration, ultimately leading to improved diagnostics, treatment, and prevention strategies for neurological diseases.
Image credit: © nobeastsofierce / stock.adobe.com
Immune mechanisms play a fundamental role in Alzheimer’s disease (AD) pathogenesis, suggesting that approaches which target immune cells and immunologically relevant molecules can offer therapeutic opportuniti...
Alzheimer’s disease (AD) involves a dynamic interaction between neuroinflammation and metabolic dysregulation, where microglia play a central role. These immune cells undergo metabolic reprogramming in respons...
Parkinson’s disease (PD) is a multi-system disorder characterized histopathologically by degeneration of dopaminergic neurons in the substantia nigra pars compacta. While the etiology of PD remains multifactorial...
The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, recognizi...
Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain ...
Many diseases and disorders of the nervous system suffer from a lack of adequate therapeutics to halt or slow disease progression, and to this day, no cure exists for any of the fatal neurodegenerative disease...
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