Neuroinflammation and Cellular Metabolism

This Collection seeks to bring together original research articles that focus on how cellular metabolism influences neuroimmune interactions and how these interactions, in turn, affect neuronal and glial function in the brain under healthy and diseased conditions. This topic is increasingly important due to the growing recognition that metabolism and immune responses in the brain are deeply interconnected, playing a crucial role in various neurological conditions. Topics may include, but are not limited to, the role of cellular immunometabolism in, neuroinflammation, neurodegeneration, neurodevelopmental disorders, and autoimmune diseases affecting the central nervous system. Submissions based solely on interrogating existing -omics datasets without follow up mechanistic studies are not encouraged.

For this Collection, we invite original research articles on the following topics (review articles will not be considered):

• Metabolic regulation of glial function (e.g. glycolysis, oxidative phosphorylation, and fatty acid metabolism in astrocytes, oligodendrocytes, and microglia)
• How cellular metabolism contributes to the progression of neuroinflammation and how this impacts neuronal and glial function and survival
• Role of the blood-brain barrier (BBB), and the blood-CSF barrier in metabolic-immune interactions
• T cell metabolism and the brain (e.g. regulatory mechanisms and function of T cell subsets)
• Neuroimmune cross-talk and metabolic pathways in neurodegenerative, neurodevelopmental, and mental health disorders
• Metabolic interventions as therapeutic targets in neuroimmunology