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Obesity and Immunosenescence

Edited by:
Professor Daniela Frasca, BSc (Biology), PhD, University of Miami, Florida, United States

Submission Status: Closed


This collection is no longer accepting submissions. 


Immunity & Ageing is calling for submissions to our collection on Obesity and Immunosenescence. Aging and obesity are high risk factors for multiple conditions and diseases. The term “adipaging” recently introduced indicates that they are both associated with inflammaging, and ameliorated by a healthy life style, clearly indicating that they may have several cellular and molecular pathways and underlying mechanisms in common.

Image: Immunofluorescence images of adipocytes from the human obese adipose tissue stained with CD1d (right) and DAPI (4’,6-diamidino-2-phenylindole), which stains the nuclei of immune cells, localized in the crown-like structures around the adipocytes. CD1d is involved in the presentation of lipids and lipoproteins to immune cells. 

Credit: Image adapted from Frasca et al. DOI: 10.3389/fimmu.2020.00392)

  1. Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory funct...

    Authors: Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen and Ruth M. Barrientos
    Citation: Immunity & Ageing 2025 22:2
    Content type: Research Published on:

  2. Antibodies are essential to immune homeostasis due to their roles in neutralizing pathogenic agents. However, failures in central and peripheral checkpoints that eliminate autoreactive B cells can undermine se...

    Authors: Taylor R. Valentino, Nan Chen, Priya Makhijani, Saad Khan, Shawn Winer, Xavier S. Revelo and Daniel A. Winer
    Citation: Immunity & Ageing 2024 21:85
    Content type: Review Published on:

  3. Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS and physical frailty is well-documented, with low-grade inflammation as potential exp...

    Authors: Martine J. Sealy, Iris M. Y. van Vliet, Harriët Jager-Wittenaar, Gerjan J. Navis and Yinjie Zhu
    Citation: Immunity & Ageing 2024 21:78
    Content type: Research Published on:

  4. Aging is a complex biological process characterized by obesity and immunosenescence throughout the organism. Immunosenescence involves a decline in immune function and the increase in chronic-low grade inflamm...

    Authors: Wei-Ching Shih, In Hwa Jang, Victor Kruglov, Deborah Dickey, Stephanie Cholensky, David A. Bernlohr and Christina D. Camell
    Citation: Immunity & Ageing 2024 21:57
    Content type: Research Published on:

  5. Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and par...

    Authors: Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes…
    Citation: Immunity & Ageing 2024 21:17
    Content type: Research Published on:

  6. Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has...

    Authors: Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery and Hamid Zand
    Citation: Immunity & Ageing 2024 21:13
    Content type: Review Published on:

    The Correction to this article has been published in Immunity & Ageing 2024 21:31

  7. Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, wit...

    Authors: L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma and F M Barbé-Tuana
    Citation: Immunity & Ageing 2023 20:51
    Content type: Research Published on:

  8. Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship b...

    Authors: Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-Hoffmann, Jakob Linseisen, Christa Meisinger and Dennis Freuer
    Citation: Immunity & Ageing 2023 20:47
    Content type: Research Published on:

About the collection

Immunity & Ageing is calling for submissions to our collection on Obesity and Immunosenescence. Aging and obesity are high risk factors for multiple conditions and diseases. The term “adipaging” recently introduced indicates that they are both associated with inflammaging, and ameliorated by a healthy life style, clearly indicating that they may have several cellular and molecular pathways and underlying mechanisms in common. A close relationship between aging and obesity is also supported by the observation that aging and obesity share other features, including oxidative stress, telomere erosion, changes in microbiota composition and epigenetic changes, all associated with health issues, and recent findings have identified dietary factors as crucial modifiers of biological age.

Obesity has also been suggested to accelerate inflammaging and immunosenescence. This seems to occur through metabolic, physiologic and functional changes in immune cells leading to dysfunctional immunity. The understanding of obesity-driven dysregulated immune cell metabolism as a cause of age-associated diseases is in the spotlight because of its pivotal role already described in inflammatory-based diseases such as cancer and autoimmune diseases. However, it is still not completely understood how metabolic alterations accumulate during aging in the different immune cells.

This Immunity & Ageing collection welcomes submissions on the following topics:

◉ Obesity-driven metabolic regulation of immunosenescence  
◉ Mechanisms underpinning the crosstalk between immunity and metabolism in obesity and aging
◉ Metabolic dysregulation of immune cell homeostasis leading to obesity-associated inflammaging
◉ Nutritional and healthy life-style interventions to prevent or delay obesity-associated inflammaging

Note: all contributions must be within the scope of the collection. The journal reserves the right to reject without review out-of-scope manuscripts. 

Submission Guidelines

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This Collection welcomes submission of Research Articles, Data Notes, Case Reports, Study Protocols, and Database Articles.

Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Obesity and Immunosenescence" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.