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Organoids and Tissue/Organ Chips

Edited by:

Professor Emeritus Albert J. Banes, PhD, University of North Carolina at Chapel Hill, United States of America and North Carolina State University Joint Department of Biomedical Engineering, Chapel Hill, North Carolina, United States of America, and President and CEO, Flexcell International Corporation, Burlington, North Carolina, Unites States of America
Rajashekhar Gangaraju, PhD, The University of Tennessee Health Science Center, United States of America

Submission Status: Closed

This collection is no longer accepting submissions.


Stem Cell Research & Therapy is calling for submissions to our collection on Organoids and Tissue/Organ Chips. The field of, “Organoids and tissue/organ chips”, represents groundbreaking advances in therapeutics, diagnostics, regenerative medicine and biomedical research. Organoids and spheroids are three-dimensional structures that mimic the architecture and function of specific organs or tissues in a laboratory setting. They are derived from pluripotent stem cells, iPSCs or adult tissue stem cells and are capable of self-organization and differentiation into various cell types. We invite authors to submit reviews/original articles describing the utility of pluripotent stem cells or adult tissue stem cells as functional units of Organoids and Tissue/Organ Chips. 

Image credit: © Alessandra Moretti / TUM/ © AlexRaths/© JOSE LUIS CALVO MARTIN & JOSE ENRIQUE GARCIA-MAURIÑO MUZQUIZ/ © pinkeyes/ © decade3d

  1. Pulmonary fibrosis models play crucial roles in research of pulmonary fibrosis and anti-fibrosis drug screening. Despite the establishment of several pulmonary fibrosis models including lung fibrosis animals, ...

    Authors: Heping Wang, Zhiyi Han, Yang Yang, Lei Liu, Yang Huang, Jiehua Chen, Yulei Wang, Zihao Liu, Lingguo Xin, Yunshan Zhao and Wenjian Wang
    Citation: Stem Cell Research & Therapy 2025 16:132
    Content type: Research Published on:

  2. Retinitis Pigmentosa (RP) is the most prevalent inherited retinal dystrophy, with more than 120 causative genes. Among them, RHO was the first photoreceptor gene described to harbor mutations responsible for RP.

    Authors: Arnau Navinés-Ferrer and Esther Pomares
    Citation: Stem Cell Research & Therapy 2025 16:71
    Content type: Research Published on:

  3. Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. Therefore, the development and fabrication of various 3D culture sy...

    Authors: Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani and Reza Rahbarghazi
    Citation: Stem Cell Research & Therapy 2025 16:45
    Content type: Research Published on:

  4. Human hematopoietic organoids have a wide application value for modeling human bone marrow diseases, such as acute hematopoietic radiation injury. However, the manufacturing of human hematopoietic organoids is...

    Authors: Keyi Chen, Yunqiao Li, Xumin Wu, Xuan Tang, Bowen Zhang, Tao Fan, Lijuan He, Xuetao Pei and Yanhua Li
    Citation: Stem Cell Research & Therapy 2024 15:133
    Content type: Research Published on:

  5. Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a promising model for studying disease mechanisms and renal development. Despite several protocols having been developed, further improvement...

    Authors: Ekaterina Pecksen, Sergey Tkachuk, Cristoph Schröder, Marc Vives Enrich, Anindita Neog, Cory P. Johnson, Niko Lachmann, Hermann Haller and Yulia Kiyan
    Citation: Stem Cell Research & Therapy 2024 15:132
    Content type: Research Published on:

  6. In response to the growing demand for organ substitutes, tissue engineering has evolved significantly. However, it is still challenging to create functional tissues and organs. Tissue engineering from the ‘bot...

    Authors: Yichen Zhan, Wenbin Jiang, Zhirong Liu, Zhenxing Wang, Ke Guo and Jiaming Sun
    Citation: Stem Cell Research & Therapy 2024 15:101
    Content type: Review Published on:

  7. Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is dif...

    Authors: Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba and Hiroyuki Mizuguchi
    Citation: Stem Cell Research & Therapy 2024 15:57
    Content type: Research Published on:

  8. Understanding mechanisms and manifestations of cardiovascular risk factors, including diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle cells, remains elusive partly ...

    Authors: Hojjat Naderi-Meshkin, Victoria A. Cornelius, Magdalini Eleftheriadou, Koray Niels Potel, Wiwit Ananda Wahyu Setyaningsih and Andriana Margariti
    Citation: Stem Cell Research & Therapy 2023 14:292
    Content type: Review Published on:

About the collection

Stem Cell Research & Therapy   is calling for submissions to our collection on Organoids and Tissue/Organ Chips. The field of, “Organoids and tissue/organ chips”, represents groundbreaking advances in therapeutics, diagnostics, regenerative medicine and biomedical research. Organoids and spheroids are three-dimensional structures that mimic the architecture and function of specific organs or tissues in a laboratory setting. They are derived from pluripotent stem cells, iPSCs or adult tissue stem cells and are capable of self-organization and differentiation into various cell types. They have revolutionized disease modeling and drug screening, allowing researchers to study human biology and pathology in a more accurate and personalized manner. Moreover, microfluidic tissue/organ chips recreate the complexity of human organs by incorporating multiple cell types, nutrient and growth factor supplies, and physiological cues, including mechanical, electrical and even magnetic signals. These chips offer a platform for studying 3D, organ-level function, disease mechanisms, and drug responses with greater precision than 2D cell culture systems. The integration of organoids and tissue/organ chips has led to the development of more realistic models for drug discovery, toxicity testing, diagnostics, therapeutics and personalized medicine, bridging the gap between in vitro experimentation and clinical applications. This thematic series aims to highlight the state of the art as these technologies continue to evolve, they hold tremendous potential for advancing our understanding of human biology and accelerating the development of novel therapies.

We invite authors to submit reviews/original articles describing the utility of pluripotent stem cells or adult tissue stem cells as functional units of Organoids and Tissue/Organ Chips.

Submission Guidelines

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This Collection welcomes submission of reviews/original articles. 

Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Editorial Manager. During the submission process you will be asked whether you are submitting to a collection, please select "Organoids and Tissue/Organ Chips" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they will handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.