Call for papers - Advancements in Physiologically based Pharmacokinetics (PBPK) models for drug development

Guest Editors

Qingfeng He, PharmD, Fudan University, China
Seung-Hyun Jeong, PhD, Sunchon National University, South Korea

Submission Status: Open | Submission Deadline: 11 July 2025

BMC Pharmacology and Toxicology is calling for submissions to our Collection on Advancements in Physiologically based Pharmacokinetics (PBPK) models for drug development. PBPK modeling is a machine learning/artificial intelligence-based approach to predicting drugs’ pharmacokinetics or toxicokinetics in humans and animals. This technique is a key player in drug discovery and development, including drug dose selection, clinical trial optimization, drug-drug interaction prediction, thereby facilitating regulatory decision-making.

This Collection aims to showcase the latest advancements, applications, and methodologies in PBPK modeling within the context of drug discovery and development.

New Content Item This Collection supports and amplifies research related to SDG 3: Good Health and Well-being.

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Meet the Guest Editors

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Qingfeng He, PharmD, Fudan University, China

Dr Qingfeng He serves as an assistant professor in the Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy at Fudan University. Dr He completed his PharmD at the University of Nebraska Medical Center in May 2020 and subsequently commenced postdoctoral training at Fudan University in September 2020, specializing in clinical pharmacology through quantitative modelling and simulation. In the past three years, Dr He has published over ten research papers. His work primarily focuses on advancing drug discovery and precision medicine through physiologically-based pharmacokinetic (PBPK) modelling, securing one national research program and three provincial fundings, with multiple translational projects in terms of drug-drug interactions and drug-induced liver injury assessment.

Seung-Hyun Jeong, PhD, Sunchon National University, South Korea

Dr Jeong received his PhD from Chonnam National University, Korea in 2019 before completing his postdoc fellowship at the University of Buffalo, USA in 2022. Currently, Dr Jeong is an Assistant Professor at Suchon National University, Korea. Dr Jeong’s research group is focused on maximizing drug treatment effects through formulation improvements and effective clinical applications. They aim to identify toxic factors from various environmental and pharmaceutical sources and contribute to human health by predicting risks from harmful substances through scientific risk assessments and mathematical modelling. The group also seeks to enhance clinical treatments by reducing side effects and improving efficacy through effective dosing regimens based on in vivo mechanisms. Their methodologies include in vivo and in vitro studies, formulation, structural biology, in silico modeling, pharmacometrics, and toxicometrics.

About the Collection

BMC Pharmacology and Toxicology is calling for submissions to our Collection on Advancements in Physiologically based Pharmacokinetics (PBPK) models for drug development.

The PBPK modeling is an orchestrated combination of computational approach and statistical interference and used for drug development. This technique advancement integrates various data, including those in vitro studies, preclinical animal test, clinical trials, and dynamic drug behavior such as absorption, distribution, metabolism, and excretion (ADME) to predict the ADME of chemical substances in humans or animal organisms. The PBPK modeling strategy displays a crucial role in drug discovery and development by supporting dose selection, optimizing clinical trial design, predicting drug-drug interactions, and facilitating regulatory decision-making.

This Collection aims to showcase the latest advancements, applications, and methodologies in PBPK modeling within the context of drug discovery and development. We welcome original research articles that explore the modeling and application of PBPK, address current challenges, and highlight future opportunities in the field.

This Collections supports and amplifies research related to SDG 3: Good Health and Well-being.

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original Research Articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Advancements in Physiologically based Pharmacokinetics (PBPK) models for drug development" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.